Safe
CO dosed in over a dozen human clinical studies to date, with tight control over blood CO levels and no major side effects
The Science & Safety of Carbon Monoxide in
Organ Transplant
Aging population and declining metabolic health have both increased need for transplants (diabetes, liver disease) and reduced quality of median donor organs. Lower quality organs increase graft dysfunction risk. 80% of potential donor lungs are declined. 20% of donor kidneys are discarded
Controlled CO-dosing has demonstrated strong cyto-protective, immuno-modulatory, anti-fibrotic and anti-inflammatory effects while demonstrating strong safety:
CO dosed in over a dozen human clinical studies to date, with tight control over blood CO levels and no major side effects
>20 studies published in preclinical transplant models, shown to